Psychopharmacology

, Volume 115, Issue 1, pp 173–179

Low doses of the 5-HT1A agonist 8-hydroxy-2-(di-n-propylamino)-tetralin (8-OH DPAT) increase ethanol intake

Authors

  • Denise M. Tomkins
    • Addiction Research Foundation
    • Departments of Pharmacology, Medicine and PsychiatryUniversity of Toronto
  • Guy A. Higgins
    • Addiction Research Foundation
    • Departments of Pharmacology, Medicine and PsychiatryUniversity of Toronto
  • Edward M. Sellers
    • Addiction Research Foundation
    • Departments of Pharmacology, Medicine and PsychiatryUniversity of Toronto
Original Investigations

DOI: 10.1007/BF02244769

Cite this article as:
Tomkins, D.M., Higgins, G.A. & Sellers, E.M. Psychopharmacology (1994) 115: 173. doi:10.1007/BF02244769

Abstract

Previous work has reported that the 5-hydroxytryptamine (5-HT)1A agonist, 8-hydroxy 2-(di-n-propylamino)tetralin (8-OH DPAT), reduces ethanol intake by rats. However, as 8-OH DPAT reduces 5-HT neurotransmission, these findings are inconsistent with the proposed inhibitory role of central 5-HT neurons on ethanol intake. We examined the effect of 8-OH DPAT on ethanol, water and food intake in rats maintained on a limited access schedule using a lower dose range (6–250 µg/kg) and by assessing concomitant changes in behaviour. Low doses of 8-OH DPAT enhanced ethanol intake even when food and water were offered as alternatives. Suppression in ethanol intake was observed at higher doses where elements of the 5-HT syndrome were apparent. Similar observations were made in both fluid and non-fluid deprived water drinking rats, suggesting the latter effect is non-selective. Therefore 8-OH DPAT may both increase or decrease ethanol consumption in the rat depending on the dose used.

Key words

Limited access scheduleEthanol intake8-OH DPATBehaviour5-HTWater deprivation
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Copyright information

© Springer-Verlag 1994