, Volume 104, Issue 1, pp 132–136

Effects of 5-HT-1A receptor agonists on CRF-induced behavior

  • Andrea J. Lazosky
  • Donald R. Britton
Original Investigations

DOI: 10.1007/BF02244567

Cite this article as:
Lazosky, A.J. & Britton, D.R. Psychopharmacology (1991) 104: 132. doi:10.1007/BF02244567


Buspirone (2.0 or 4.0 mg/kg) and 8-hydroxy-2-(di-N-propylamino)-tetralin (8-OH-DPAT) (0.25 or 0.5 mg/kg) were used to examine the effects of serotonin 1A receptor agonists on the behavioral response of rats to centrally administered corticotropin-releasing factor (CRF). Behavioral observations were done with animals in their home cages. Parameters measured included locomotor activity, grooming and food consumption. CRF alone increased locomotor activity. 8-OH-DPAT also increased locomotion in both saline control and CRF-treated rats. Buspirone had no effect on basal locomotion or on CRF-induced hyperactivity. Both buspirone and 8-OH-DPAT antagonized CRF-induced grooming. Food consumption by fasted rats was suppressed by ICV CRF. 8-OH-DPAT suppressed eating by both ICV CRF and ICV saline-treated animals, while buspirone was without effect. These results demonstrate differences between the two putative 5-HT-1A agonists in their effects on CRF-induced behavior but also demonstrate that both suppress CRF-induced grooming.

Key words

CRF 8-OH-DPAT Buspirone Locomotor activity Grooming Anxiolytic 

Copyright information

© Springer-Verlag 1991

Authors and Affiliations

  • Andrea J. Lazosky
    • 1
  • Donald R. Britton
    • 1
    • 2
  1. 1.Department of Pharmacology and Molecular BiologyUniversity of Health Sciences, Chicago Medical SchoolChicago, KUSA
  2. 2.Neuroscience Research Division (47U)Pharmaceutical Discovery Abbott Laboratories, AP10Abbott ParkUSA

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