Psychopharmacology

, Volume 113, Issue 1, pp 51–52

Reinforcing effect of the D1 dopamine agonist SKF 81297 in rhesus monkeys

Authors

  • Michael R. Weed
    • Department of Pharmacological and Physiological SciencesUniversity of Chicago
  • Kimberly E. Vanover
    • Committee on BiopsychologyUniversity of Chicago
  • William L. Woolverton
    • Department of Pharmacological and Physiological SciencesUniversity of Chicago
    • Committee on BiopsychologyUniversity of Chicago
    • Department of Psychiatry, Drug Abuse Research Center, Pritzker School of MedicineUniversity of Chicago
Original Investigations

DOI: 10.1007/BF02244333

Cite this article as:
Weed, M.R., Vanover, K.E. & Woolverton, W.L. Psychopharmacology (1993) 113: 51. doi:10.1007/BF02244333

Abstract

Rhesus monkeys with IV catheters were allowed to self-administer cocaine for 1 h/day. When responding was stable, saline or the D1 dopamine agonist SKF 81297 (SKF; 0.001–0.3 mg/kg/inj) was substituted for cocaine. At least two doses of SKF maintained responding above saline levels in all monkeys. The D1 antagonist SCH 39166 (0.001–0.03 mg/kg, IM) was then administered 30 min before sessions of self-administration of the lowest dose of SKF that maintained behavior (0.01 mg/kg/inj). SKF-maintained responding decreased in a dose-related manner, suggesting antagonism of the reinforcing effect. These results suggest that stimulation of D1 receptors can initiate a reinforcing effect and further implicate D1 receptors in the reinforcing effects of drugs that increase dopamine neurotransmission.

Key words

Self-administrationDopamineD1 receptors

Copyright information

© Springer-Verlag 1993