Psychopharmacology

, Volume 101, Issue 3, pp 414–420

Schizophrenic-like sensorimotor gating abnormalities in rats following dopamine infusion into the nucleus accumbens

  • N. R. Swerdlow
  • D. L. Braff
  • V. L. Masten
  • M. A. Geyer
Original Investigations

DOI: 10.1007/BF02244063

Cite this article as:
Swerdlow, N.R., Braff, D.L., Masten, V.L. et al. Psychopharmacology (1990) 101: 414. doi:10.1007/BF02244063
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Abstract

Previous studies have demonstrated that several dopamine agonists disrupt sensorimotor gating as measured by prepulse inhibition (PPI) of the acoustic startle response (ASR) in rats. Schizophrenic patients also exhibit deficits in PPI when the prepulse preceeds the startle stimulus by less than 500 ms. In experiment 1, dopamine (0–40 µg) infused directly into the nucleus accumbens in rats caused a dose-dependent decrease in PPI at prepulse intervals shorter than 500 ms. In experiment 2, this effect of accumbens dopamine infusions on sensorimotor gating was found to vary with changes in prepulse intensity. These findings strongly suggest that increased mesolimbic dopamine activity is one substrate of the sensorimotor gating deficits in rats that are caused by treatment with dopamine agonists; similar substrates might mediate deficits in PPI exhibited by schizophrenic patients.

Key words

Acoustic startle response Dopamine Nucleus accumbens Prepulse inhibition Schizophrenia Sensorimotor gating 

Copyright information

© Springer-Verlag 1990

Authors and Affiliations

  • N. R. Swerdlow
    • 1
  • D. L. Braff
    • 1
  • V. L. Masten
    • 1
  • M. A. Geyer
    • 1
  1. 1.Department of Psychiatry, T-004University of California at San DiegoLa JollaUSA

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