Psychopharmacology

, Volume 100, Issue 4, pp 530–534

Competition for sucrose-pellets in triads of male wistar rats: effects of acute and subchronic chloridazepoxide

  • C. Gentsch
  • M. Lichtsteiner
  • H. Feer
Original Investigations

DOI: 10.1007/BF02244007

Cite this article as:
Gentsch, C., Lichtsteiner, M. & Feer, H. Psychopharmacology (1990) 100: 530. doi:10.1007/BF02244007
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Abstract

Within triads of male Wistar rats, some animals almost completely abstain from competition for palatable sucrose pellets (so-called poor-performing rats), whereas other rats consistently win the competition (so-called high-performing rats). Subchronic (5 mg/kg; 5 consecutive days), but not acute (0.1–20 mg/kg), treatment with chlordiazepoxide temporarily helped poor-performing rats to behave more competitively. This finding, considered together with parallel studies (using high-performing rats), suggested that chloridazepoxide's beneficial effect was only demonstrable when the poor-performing rats had become tolerant to the drug's initial sedative effect.

Key words

CompetitionChloridazepoxideSucroseBehavioral inhibitionRat

Copyright information

© Springer-Verlag 1990

Authors and Affiliations

  • C. Gentsch
    • 1
  • M. Lichtsteiner
    • 1
  • H. Feer
    • 1
  1. 1.Psychiatric University Clinic Basle, Biochemical LaboratoryBasleSwitzerland