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Constitutional hyperbilirubinemia with unconjugated bilirubin in the serum and pigment deposition in the liver

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Summary

A case of constitutional hyperbilirubinemia with mild elevations of un-conjugated bilirubin in the serum was reported which was further characterized by an accumulation of pigment granules in the liver cells of the Dubin-Johnson-Sprinz-Nelson type. Electron-microscopic studies demonstrated predominantly lipofuscin-like pigments in the liver cells. The pathogenesis of this condition and the chemical nature of these pigments were briefly discussed. Attention was called to a variant of the Gilbert-Meulengracht syndrome.

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Authors and Affiliations

  1. From the Departments of Hospital Clinics and Internal Medicine, Walter Reed General Hospital, Washington, D. C.

    John D. Herman M.D., Everett B. Cooper M.D., Akio Takeuchi M.D. & Helmuth Sprinz M.D.

  2. the Department of Experimental Pathology, Walter Reed Army Institute of Research, Washington, D. C.

    John D. Herman M.D., Everett B. Cooper M.D., Akio Takeuchi M.D. & Helmuth Sprinz M.D.

Authors
  1. John D. Herman M.D.
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  2. Everett B. Cooper M.D.
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  3. Akio Takeuchi M.D.
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  4. Helmuth Sprinz M.D.
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Additional information

The authors wish to express their appreciation to Irwin M. Arias, M.D., for his diazotization and paper chromatographic analysis of the patient's serum.

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Herman, J.D., Cooper, E.B., Takeuchi, A. et al. Constitutional hyperbilirubinemia with unconjugated bilirubin in the serum and pigment deposition in the liver. Digest Dis Sci 9, 160–169 (1964). https://doi.org/10.1007/BF02243521

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  • DOI: https://doi.org/10.1007/BF02243521

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