Case Report

Clinical Rheumatology

, Volume 16, Issue 3, pp 305-309

First online:

Systemic lupus erythmatosus associated with autoimmune hepatitis two cases with novel autoantibodies to transfer RNA-related antigens

  • T. SatohAffiliated withSection of Rheumatology, Department of Internal Medicine, Keio University School of Medicine
  • , M. HirakataAffiliated withSection of Rheumatology, Department of Internal Medicine, Keio University School of Medicine
  • , T. YoshidaAffiliated withSection of Rheumatology, Department of Internal Medicine, Keio University School of Medicine
  • , M. MatsumuraAffiliated withSection of Rheumatology, Department of Internal Medicine, Keio University School of Medicine
  • , K. MiyachiAffiliated withHealth and Science Research Institute
  • , T. MimoriAffiliated withSection of Rheumatology, Department of Internal Medicine, Keio University School of Medicine
  • , M. AkizukiAffiliated withSection of Rheumatology, Department of Internal Medicine, Keio University School of Medicine

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Summary

Two cases of systemic lupus erythematosus (SLE) with autoimmune hepatitis are reported. Both patients had a mild form of SLE without central nervous system or renal involvement and showed a rapid response to corticosteroid therapy. Neither of them had antibodies to mitochondria, smooth muscle, and liver/kidney microsome-1 related to autoimmune hepatitis. Instead, novel autoantibodies which react with transfer RNA-related antigen were detected. These autoantibodies could be a useful marker for classification of SLE associated with autoimune hepatitis.

Key words

Systemic Lupus Erythematosus Autoimmune Hepatitis Autoantibodies Anti-transfer RNA-related Antibodies