Case Report

The American Journal of Digestive Diseases

, Volume 16, Issue 11, pp 1014-1018

First online:

Hepatitis, arthritis and lupus cell phenomena caused by methyldopa

  • Michael EliastamAffiliated withFrom the Section of Hepatology, Department of Medicine, Rush-Presbyterian-St. Luke's Medical Center
  • , A. W. HolmesAffiliated withFrom the Section of Hepatology, Department of Medicine, Rush-Presbyterian-St. Luke's Medical Center

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Summary

A patient is described who developed hepatocellular jaundice after methyldopa was administered. When the drug was again prescribed, hepatitis recurred. This exacerbation, along with transient arthritis, antinuclear antibodies and positive LE cell tests, document this as a case of hepatotoxicity due to methyldopa.