Hepatitis, arthritis and lupus cell phenomena caused by methyldopa Authors
Cite this article as: Eliastam, M. & Holmes, A.W. Digest Dis Sci (1971) 16: 1014. doi:10.1007/BF02235014 Summary
A patient is described who developed hepatocellular jaundice after methyldopa was administered. When the drug was again prescribed, hepatitis recurred. This exacerbation, along with transient arthritis, antinuclear antibodies and positive LE cell tests, document this as a case of hepatotoxicity due to methyldopa.
Fries J, Siraganian R: Sulfonamide hepatitis; report of a case due to sulfamethoxazole and sulfisoxazole. New Eng J Med 274:95–97, 1966
Reubner BH, Slusser RJ: Hepatocytes and sinusoidal lining cells in viral hepatitis; an electron microscopic study. Arch Path 86:1–11, 1968
Elkington SG, Schreiber WM, Conn HO: Hepatic injury caused by L-alpha methyldopa. Circulation 40:589–595, 1969
Zarday Z, Rosenthal WS, Wolff FW: Severe liver toxicity after methyl-dopa. New York J Med 67:1897, 1967
Horwitz D, Pettinger WA, Orvis H, et al: Effects of methyldopa in 50 hypertensive patients. Clin Pharmacol Ther 8:224–234, 1967.
Sherman JD, Love DE, Harrington JF: Anemia, positive lupus and rheumatoid factors with methyldopa. Arch Intern Med 120:321–326, 1967
© Hoeber Medical Division • Harper & Row, Publishers, Incorporated 1971