Effects of nicotine and tobacco smoke on gastric secretion in rats with gastric fistulas
Cite this article as: Thompson, J.H. Digest Dis Sci (1970) 15: 209. doi:10.1007/BF02233450 Abstract
A light-weight plastic cannula was surgically implanted in the stomach at the nonglandular/glandular mucosal junction in male Sprague-Dawley rats. After a 3-week recovery period they were studied repeatedly over a span of 9 months. Following a 48-hr fast, gastric secretion was collected hourly for 7 hr (1 control and 6 experimental); parameters measured were gastric-juice volume (GJV), acid output (AOP), and pepsin output (POP).
The effects of nicotine hydrogen tartrate and tobacco smoke in 10% ethanol saline were studied under basal conditions and after stimulation with maximal doses of histamine acid phosphate and submaximal and maximal doses of ICI-50123. In control experiments, rats received normal saline or 10% ethanol saline (tobacco smoke control).
Nicotine depressed, to a varying degree, GJV and AOP in 3 hr of basal secretion; POP was unaffected. With maximal histamine-stimulated secretion, nicotine depressed GJV and AOP, to a varying degree, over the third to seventh hour; POP was depressed from the second to seventh hour. With maximal ICI-50123-stimulated secretion, nicotine depressed POP from the second to seventh hour; no effect was seen on the other parameters. With submaximal ICI-50123-stimulated secretion, POP was depressed by both nicotine and tobacco smoke; the other parameters were unaffected.
Supported in part by a grant from the American Medical Association Education and Research Foundation.
Thanks are due Charles A. Spezia and Manuel Angulo for technical assistance, Dr. T. Robitscher, of Ayerst Laboratories, Inc., for the ICI-50123, and Dr. Rolf Håkanson for the gastric cannulas.
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