Histamine release from canine lung and liver mast cells induced by radiographic contrast media
Rent the article at a discountRent now
* Final gross prices may vary according to local VAT.Get Access
Radiographic contrast media are commonly used diagnostic aids to improve imaging, e.g. in computerized tomography. However, the routine application of these agents may cause adverse allergic/pseudoallergic reactions. In order to understand more completely the underlying mechanisms involved in these reactions, experiments on histamine release bothin vivo andin vitro are necessary. Using canine mast cell suspensions from lung and liver, we have investigated the histamine release caused by six commonly used preparations. The dog is an ideal model for bothin vitro andin vivo studies not only by virtue of its size but also because of its similarity to man with respect to e.g. cardiovascular reactions after drug-induced histamine release. The two non-ionic preparations (Solutrast, Ultravist) released little histamine from both cell types (ca. 4–6%). The ionic contrast media (Angiographin, Hexabrix, Telebrix, Rayvist) dose-dependently released histamine from the liver cells and pulmonary cells (maximum release between 18–35%). The liver cells (the liver is the shock organ in the dog) reacted more strongly to these agents than the pulmonary cells, thus providing further evidence for mast cell heterogeneity and the importance of selecting the appropriate mast cell model for the investigation.
- U. Speck, W. Mützel and H. J. Weinmann,Chemistry, physiochemistry and pharmacology of known and new contrast media for angiography, urography and CT enhancement. In:Contrast media in urography, angiography and computerized tomography (Eds. V. Taenzer and E. Zeiler) pp. 2–10. Thieme, Stuttgart 1983.
- H. K. Beyer, R. Kakulies, W. G. H. Schmitt and B. Schulze,Nebeneffekte und Komplikationen nach Röntgenkontrastmittelgabe—Risikoverminderung und Prävention. Röntgenpraxis40, 459–465 (1987).
- C. M. Herd, A. R. Noberson, D. B. Frewin and W. B. Taylor,Adverse reactions during intravenous urography: are these due to histamine release? Br. J. Radiol.61, 5–11 (1988).
- M. Ennis, W. Lorenz, W. Gerland and J. Heise,Isolation of mast cells from rabbit lung and liver: Comparison of histamine release induced by the hypnotics Althesin ® and propanidid. Agents and Actions20, 219–222 (1987).
- M. Ennis,Histamine release from human pulmonary mast cells. Agents and Actions12, 60–63 (1982).
- F. L. Pearce, M. Ennis, A. Truneh and J. R. White,Role of intra- and extracellular calcium in histamine release from rat peritoneal mast cells. Agents and Actions11, 51–54 (1981).
- E. S. K. Assem and K. Bray,The release of histamine from human basophils by radiological contrast agents. Br. J. Radiol.56, 647–652 (1983).
- J. Ring and K. H. Rothenberger,Anaphylaktoide Reaktionen nach Infusion von Röntgenkontrastmittel. Münch. med. Wschr.126, 657–661 (1984).
- Histamine release from canine lung and liver mast cells induced by radiographic contrast media
Agents and Actions
Volume 27, Issue 1-2 , pp 101-103
- Cover Date
- Print ISSN
- Online ISSN
- Additional Links
- Industry Sectors