Digestive Diseases and Sciences

, Volume 40, Supplement 2, pp 63S–80S

Safety of acid-suppressing drugs

Authors

  • Richard A. Smallwood
    • Department of MedicineHeidelberg Repatriation Hospital
    • Merck, Sharp and Dohme Research Laboratories
    • Virginia Polytechnic Institute and State University
    • Department of MedicineUniversity of Connecticut
    • Department of MedicineUniversity Hospital, Queens Medical Centre
    • Department of MedicineUniversity of Hong Kong
    • University Departmetn of Therapeutics
    • Astra Hässle AB
    • Department of Pharmacology, Toxicology and TherapeuticsUniversity of Kansas Medical Center
  • Roger G. Berlin
    • Department of MedicineHeidelberg Repatriation Hospital
    • Merck, Sharp and Dohme Research Laboratories
    • Virginia Polytechnic Institute and State University
    • Department of MedicineUniversity of Connecticut
    • Department of MedicineUniversity Hospital, Queens Medical Centre
    • Department of MedicineUniversity of Hong Kong
    • University Departmetn of Therapeutics
    • Astra Hässle AB
    • Department of Pharmacology, Toxicology and TherapeuticsUniversity of Kansas Medical Center
  • Neal Castagnoli
    • Department of MedicineHeidelberg Repatriation Hospital
    • Merck, Sharp and Dohme Research Laboratories
    • Virginia Polytechnic Institute and State University
    • Department of MedicineUniversity of Connecticut
    • Department of MedicineUniversity Hospital, Queens Medical Centre
    • Department of MedicineUniversity of Hong Kong
    • University Departmetn of Therapeutics
    • Astra Hässle AB
    • Department of Pharmacology, Toxicology and TherapeuticsUniversity of Kansas Medical Center
  • Henk P. M. Festen
    • Department of MedicineHeidelberg Repatriation Hospital
    • Merck, Sharp and Dohme Research Laboratories
    • Virginia Polytechnic Institute and State University
    • Department of MedicineUniversity of Connecticut
    • Department of MedicineUniversity Hospital, Queens Medical Centre
    • Department of MedicineUniversity of Hong Kong
    • University Departmetn of Therapeutics
    • Astra Hässle AB
    • Department of Pharmacology, Toxicology and TherapeuticsUniversity of Kansas Medical Center
  • Christopher J. Hawkey
    • Department of MedicineHeidelberg Repatriation Hospital
    • Merck, Sharp and Dohme Research Laboratories
    • Virginia Polytechnic Institute and State University
    • Department of MedicineUniversity of Connecticut
    • Department of MedicineUniversity Hospital, Queens Medical Centre
    • Department of MedicineUniversity of Hong Kong
    • University Departmetn of Therapeutics
    • Astra Hässle AB
    • Department of Pharmacology, Toxicology and TherapeuticsUniversity of Kansas Medical Center
  • S. K. Lam
    • Department of MedicineHeidelberg Repatriation Hospital
    • Merck, Sharp and Dohme Research Laboratories
    • Virginia Polytechnic Institute and State University
    • Department of MedicineUniversity of Connecticut
    • Department of MedicineUniversity Hospital, Queens Medical Centre
    • Department of MedicineUniversity of Hong Kong
    • University Departmetn of Therapeutics
    • Astra Hässle AB
    • Department of Pharmacology, Toxicology and TherapeuticsUniversity of Kansas Medical Center
  • Michael J. S. Langman
    • Department of MedicineHeidelberg Repatriation Hospital
    • Merck, Sharp and Dohme Research Laboratories
    • Virginia Polytechnic Institute and State University
    • Department of MedicineUniversity of Connecticut
    • Department of MedicineUniversity Hospital, Queens Medical Centre
    • Department of MedicineUniversity of Hong Kong
    • University Departmetn of Therapeutics
    • Astra Hässle AB
    • Department of Pharmacology, Toxicology and TherapeuticsUniversity of Kansas Medical Center
  • Per Lundborg
    • Department of MedicineHeidelberg Repatriation Hospital
    • Merck, Sharp and Dohme Research Laboratories
    • Virginia Polytechnic Institute and State University
    • Department of MedicineUniversity of Connecticut
    • Department of MedicineUniversity Hospital, Queens Medical Centre
    • Department of MedicineUniversity of Hong Kong
    • University Departmetn of Therapeutics
    • Astra Hässle AB
    • Department of Pharmacology, Toxicology and TherapeuticsUniversity of Kansas Medical Center
  • Andrew Parkinson
    • Department of MedicineHeidelberg Repatriation Hospital
    • Merck, Sharp and Dohme Research Laboratories
    • Virginia Polytechnic Institute and State University
    • Department of MedicineUniversity of Connecticut
    • Department of MedicineUniversity Hospital, Queens Medical Centre
    • Department of MedicineUniversity of Hong Kong
    • University Departmetn of Therapeutics
    • Astra Hässle AB
    • Department of Pharmacology, Toxicology and TherapeuticsUniversity of Kansas Medical Center
Article

DOI: 10.1007/BF02214872

Cite this article as:
Smallwood, R.A., Berlin, R.G., Castagnoli, N. et al. Digest Dis Sci (1995) 40: 63S. doi:10.1007/BF02214872

Abstract

There is an extensive literature on the adverse effects of drugs that inhibit gastric acid secretion. This study presents a critical examination of interactions between antisecretory drugs and other compounds, the frequency of serious adverse effects relating to various body systems, the safety of antisecretory drugs in pregnancy, and longer-term safety data from postmarketing surveillance studies. While interactions with some other drugs, alcohol, and certain carcinogens are of potential concern, in practice clinically significant reactions appear to be rare if they occur at all. A small number of major side-effects have been documented, but they occur rarely, and postmarketing surveillance has not detected other longer-term sequelae. Safety of these drugs in pregnancy is not established, as data are so few. It is concluded that antisecretory agents, by comparison with most other classes of drugs, are remarkably well tolerated.

Key Words

antisecretory drugs drug-drug interactions drugs in pregnancy drug toxicity gastric ADH P-450 induction P-450 inhibition surveillance

Copyright information

© Plenum Publishing Corporation 1995