Digestive Diseases and Sciences

, Volume 40, Issue 9, pp 1941–1945

Hemodynamic effects of hypothyroidism induced by methimazole in normal and portal hypertensive rats

Authors

  • Ran Oren
    • Department of MedicineHadassah University Hospital
    • Hepatic Hemodynamic Laboratory, Department of Medicine, Soroka Medical Center and Faculty of Health SciencesBen-Gurion University of the Negev
  • Nir Hilzenrat
    • Department of MedicineHadassah University Hospital
    • Hepatic Hemodynamic Laboratory, Department of Medicine, Soroka Medical Center and Faculty of Health SciencesBen-Gurion University of the Negev
  • Yoram Maaravi
    • Department of MedicineHadassah University Hospital
    • Hepatic Hemodynamic Laboratory, Department of Medicine, Soroka Medical Center and Faculty of Health SciencesBen-Gurion University of the Negev
  • Arie Yaari
    • Department of MedicineHadassah University Hospital
    • Hepatic Hemodynamic Laboratory, Department of Medicine, Soroka Medical Center and Faculty of Health SciencesBen-Gurion University of the Negev
  • Emanuel Sikuler
    • Department of MedicineHadassah University Hospital
    • Hepatic Hemodynamic Laboratory, Department of Medicine, Soroka Medical Center and Faculty of Health SciencesBen-Gurion University of the Negev
Liver: Cirrhosis, Fibrosis, Portal Hypertension, and Transplantation

DOI: 10.1007/BF02208661

Cite this article as:
Oren, R., Hilzenrat, N., Maaravi, Y. et al. Digest Dis Sci (1995) 40: 1941. doi:10.1007/BF02208661

Abstract

Portal hypertension is accompanied by a hyperdynamic circulatory state that shares some similarities with thyrotoxicosis. This study was conducted in order to investigate the hemodynamic effects of hypothyroidism in a rat model with portal hypertension induced by partial portal vein ligation (PVL). Four groups of 10 rats each were studied: normal control and hypothyroid rats, and PVL control and hypothyroid rats. Hypothyroidism was induced by methimazole 0.04% in drinking water. Hemodynamic measurements were performed using the radioactive microsphere technique. Induction of hypothyroidism was confirmed by elevated TSH levels. In the PVL groups, hypothyroidism ameliorated the hyperdynamic circulation. Portal venous inflow and portal pressure dropped significantly: 7.1±0.2 vs 4.8±0.3 ml/min/100 g body wt (P<0.01) and 13.4±0.9 vs 10.9±0.8 mm Hg; (P<0.01), respectively. In normal rats, hypothyroidism was manifested by a hypodynamic circulatory state. These results demonstrate that hypothyroidism induced by methimazole is followed by amelioration of the hyperdynamic circulation, normalization of portal venous inflow, and reduction of portal pressure.

Key Words

portal hypertensionhypothyroidismhemodynamicsmethimazoleportal vein ligation

Copyright information

© Plenum Publishing Corporation 1995