Journal of Molecular Evolution

, Volume 43, Issue 6, pp 610–621

Determinants of rate variation in mammalian DNA sequence evolution

Authors

  • Lindell Bromham
    • Department of ZoologyUniversity of Oxford
  • Andrew Rambaut
    • Department of ZoologyUniversity of Oxford
  • Paul H. Harvey
    • Department of ZoologyUniversity of Oxford
Articles

DOI: 10.1007/BF02202109

Cite this article as:
Bromham, L., Rambaut, A. & Harvey, P.H. J Mol Evol (1996) 43: 610. doi:10.1007/BF02202109

Abstract

Attempts to analyze variation in the rates of molecular evolution among mammalian lineages have been hampered by paucity of data and by nonindependent comparisons. Using phylogenetically independent comparisons, we test three explanations for rate variation which predict correlations between rate variation and generation time, metabolic rate, and body size. Mitochondrial and nuclear genes, protein coding, rRNA, and nontranslated sequences from 61 mammal species representing 14 orders are used to compare the relative rates of sequence evolution. Correlation analyses performed on differences in genetic distance since common origin of each pair against differences in body mass, generation time, and metabolic rate reveal that substitution rate at fourfold degenerate sites in two out of three protein sequences is negatively correlated with generation time. In addition, there is a relationship between the rate of molecular evolution and body size for two nuclear-encoded sequences. No evidence is found for an effect of metabolic rate on rate of sequence evolution. Possible causes of variation in substitution rate between species are discussed.

Key words

Molecular evolutionMolecular clockPhylogenyMetabolic rateGeneration timeBody sizeAllometry
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Copyright information

© Springer-Verlag New York Inc. 1996