Behavior Genetics

, Volume 25, Issue 2, pp 133–147

Personality, psychopathology, and nicotine response as mediators of the genetics of smoking

  • David G. Gilbert
  • Brenda O. Gilbert

DOI: 10.1007/BF02196923

Cite this article as:
Gilbert, D.G. & Gilbert, B.O. Behav Genet (1995) 25: 133. doi:10.1007/BF02196923


Individual differences in psychopathology, personality, and nicotine responsitivity and their biological bases are evaluated as mechanisms potentially mediating smoking heritability. Smokers are more likely to be high in neurotic traits (e.g., depression, anxiety, anger) and in social alienation (psychoticism, impulsivity, unsocialized sensation-seeking, low conscientiousness, low agreeableness) and low in achievement/socioeconomic status. Psychological and biological mechanisms putatively mediating these associations are reviewed. It is concluded that a number of relatively indirect and complex processes, as well as more direct (e.g., self-medication for psychopathology, nicotine sensitivity), mediate the inheritance of smoking behavior.

Key Words


Copyright information

© Plenum Publishing Corporation 1995

Authors and Affiliations

  • David G. Gilbert
    • 1
  • Brenda O. Gilbert
    • 1
  1. 1.Department of PsychologySouthern Illinois UniversityCarbondale