Noctural myoclonus syndrome (periodic movements in sleep) related to central dopamine D2-receptor alteration

  • J. Staedt
  • G. Stoppe
  • A. Kögler
  • H. Riemann
  • G. Hajak
  • D. L. Munz
  • D. Emrich
  • E. Rüther
Original Paper

DOI: 10.1007/BF02191538

Cite this article as:
Staedt, J., Stoppe, G., Kögler, A. et al. Eur Arch Psychiatry Clin Nuerosci (1995) 245: 8. doi:10.1007/BF02191538

Abstract

The nocturnal myoclonus syndrome (NMS) consists of stereotyped, repetitive jerks of the lower limbs that occur during sleep or wakefulness. NMS is often related with restless-legs syndrome (RLS) and can cause severe sleep disturbances and daytime sleepiness. The efficacy of dopamine agonists in the treatment points to a dopaminergic dysfunction in NMS. We investigated the central dopamine D2-receptor occupancy with [123I] labeled (S)-2-hydroxy-3-iodo-6-methoxy-([1-ethyl-2-pyrrolidinyl]methyl) benzamide (IBZM) (a highly selective CNS D2 dopamine receptor ligand) ([123I]IBZM) and single photon emission tomography (SPET) in 20 patients with NMS and in 10 healthy controls. In most of the patients with NMS there was a lower [123I]IBZM binding in the striatal structures compared to controls. The results indicate that NMS is related to a decrease of central D2-receptor occupancy.

Key words

Nocturnal myoclonus syndrome (NMS)Restless-legs syndrome (RLS)[123I]IBZMSPETDopamine

Copyright information

© Springer-Verlag 1995

Authors and Affiliations

  • J. Staedt
    • 1
  • G. Stoppe
    • 1
  • A. Kögler
    • 2
  • H. Riemann
    • 1
  • G. Hajak
    • 1
  • D. L. Munz
    • 3
  • D. Emrich
    • 2
  • E. Rüther
    • 1
  1. 1.Department of PsychiatryUniversity of GoettingenGoettingenGermany
  2. 2.Department of Nuclear MedicineGeorg August UniversityGottingenGermany
  3. 3.Department of Nuclear MedicineHumboldt University (Charité)BerlinGermany