Living Pediatrics Symposium in Honour of the 80th Birthday of Professor E. Rossi, Berne, Switzerland

European Journal of Pediatrics

, Volume 154, Supplement 4, pp S60-S64

First online:

Immunthrombocytopenic purpura as a model for pathogenesis and treatment of autoimmunity

  • P. ImbachAffiliated withKinderklinik AarauUniversitäts-Kinderspital
  • , J. AkatsukaAffiliated withThe Daisan Hospital
  • , V. BlanchetteAffiliated withHospital for Sick Children
  • , A. Burek-KozlowskaAffiliated withCentral Laboratory, SRK
  • , J. BusselAffiliated withCornell University
  • , G. GaedickeAffiliated withUniversitäts-Kinderklinik Charlottenburg
  • , A. Gianella-BorradoriAffiliated withSandoz
  • , E. GuglerAffiliated withKinderklinik Inselspital
  • , A. HirtAffiliated withKinderklinik Inselspital
    • , B. ImholzAffiliated withKinderklinik Inselspital
    • , R. McMillanAffiliated withScripps Clinic
    • , A. MorellAffiliated withCentral Laboratory, SRK
    • , A. NewlandAffiliated withThe London Hospital
    • , D. NugentAffiliated withChildren's Hospital
    • , M. H. SchöniAffiliated withAlpine Children's Hospital
    • , H. P. WagnerAffiliated withKinderklinik Inselspital

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Abstract

In honour of Professor Rossi's 80th birthday we review the development of our understanding of the immune and auto-immune nature of the pathogenesis of immune thrombocytopenic purpura (ITP). The immune aspects have been documented by postviral alterations of the cellular and humoral immune system, by new methods of specific auto-antibody detection against platelet glycoproteins and by the therapeutic effect of administering immunoglobulin concentrate from healthy blood donors. The various possible mechanisms of action of immunoglobulin treatment have led to use of this treatment as an alternative for other immune-related disorders. The treatment of severe chronic ITP in children, however, remains unsatisfactory. With a new international clinical and laboratory study of children and adolescents with early chronic ITP we are continuing the investigation of the pathogenesis and treatment of ITP.

Key words

Immune thrombocytopenic purpura Auto-antibodies Against platelets Immunoglobulin