Human Genetics

, Volume 97, Issue 3, pp 283–286

Molecular studies of the aetiology of trisomy 8 in spontaneous abortions and the liveborn population

  • Rowena Sarah James
  • Patricia Ann Jacobs
Original investigation

DOI: 10.1007/BF02185754

Cite this article as:
James, R.S. & Jacobs, P.A. Hum Genet (1996) 97: 283. doi:10.1007/BF02185754

Abstract

We have determined the parental origin in eight cases of constitutional trisomy 8. In all four cases of spontaneous abortion, the additional chromosome was maternal in origin and there was evidence for nullichiasmate meiosis I occurring in the genesis of this trisomy. In contrast, all four cases of liveborn trisomy 8 appear to have arisen by a mechanism consistent with the post-zygotic mitotic gain of the additional chromosome.

Copyright information

© Springer-Verlag 1996

Authors and Affiliations

  • Rowena Sarah James
    • 1
  • Patricia Ann Jacobs
    • 1
  1. 1.Wessex Regional Genetics LaboratorySalisbury District HospitalSalisburyUK