Effect of levodopa on the human pattern electroretinogram and pattern visual evoked potentials

  • Irene Gottlob
  • Herbert Weghaupt
  • Clemens Vass
  • Eduard Auff
Clinical Investigations

DOI: 10.1007/BF02172892

Cite this article as:
Gottlob, I., Weghaupt, H., Vass, C. et al. Graefe's Arch Clin Exp Ophthalmol (1989) 227: 421. doi:10.1007/BF02172892

Abstract

Pattern electroretinograms (P-ERGs) and pattern visual evoked potentials (P-VEPs) were recorded at three luminance levels and five different check sizes in a group of 16 control subjects before and after the oral administration of levodopa. At the lower luminance levels, significant decrease in P-ERG and P-VEP latencies were found. For P-VEPs the latency changes occurred only at small check sizes. No changes were observed in control experiments without levodopa administration. Our results show that levodopa-induced changes even occur at the retinal level and support a dopaminergic involvement in light and dark adaptation. Our observations are in agreement with a VEP delay found in Parkinson's disease and with a VEP latency increase in rats after dopamine depletion.

Copyright information

© Springer-Verlag, Berlin Heidelberg 1989

Authors and Affiliations

  • Irene Gottlob
    • 1
  • Herbert Weghaupt
    • 1
  • Clemens Vass
    • 1
  • Eduard Auff
    • 2
  1. 1.I. Universitäts-AugenklinikWienAustria
  2. 2.Neurologische Universitäts-KlinikWienAustria

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