Perspectives in Drug Discovery and Design

, Volume 4, Issue 1, pp 17–40

The chirality problem in P-substituted oligonucleotides

  • Alexandre V. Lebedev
  • Eric Wickstrom

DOI: 10.1007/BF02172106

Cite this article as:
Lebedev, A.V. & Wickstrom, E. Perspectives in Drug Discovery and Design (1996) 4: 17. doi:10.1007/BF02172106


P-substituted oligonucleotides, which are oligonucleotide analogs where one (or more) bridging or nonbridging oxygen(s) of an internucleotide bond is substituted by another atom or group of atoms, are being studied as novel potential therapeutics. A chirality problem associated with the substitution of nonbridging oxygen is discussed. Synthesis, structure, hybridization and biological properties of the individual diastereomers of P-substituted oligonucleotides are reviewed.

Copyright information

© ESCOM Science Publishers B.V. 1996

Authors and Affiliations

  • Alexandre V. Lebedev
    • 1
  • Eric Wickstrom
    • 2
  1. 1.Genta, Inc.San DiegoUSA
  2. 2.Department of PharmacologyThomas Jefferson UniversityPhiladelphiaUSA