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Stimulation of hematopoiesis and antibacterial resistance by interleukin-1

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Biotherapy

Summary

The beneficial effects of IL-1 and other cytokines on hematopoiesis and on resistance to infection are profound. IL-1 stimulates proliferation of bone marrow cells in normal mice and potentiates the recovery of peripheral blood neutrophils in mice with drug-induced neutropenia. Prophylactic cytokine administration provides an elevated level of natural resistance to infections which is correlated with increased numbers of phagocytic leukocytes. These studies suggest that IL-1 has potential clinical application as a therapy to limit bone marrow dysfunction and immuno-suppression and to augment hematopoiesis and natural immunity. Further research will continue to elucidate the mechanisms whereby interleukins and colony-stimulating factors act, and interact, to promote restoration of leukocyte production and to enhance host resistance.

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Authors and Affiliations

  1. Hoffmann-LaRoche Inc., Roche Research Center, 07110, Nutley, NJ, USA

    Kim W. McIntyre, Joel Unowsky, William DeLorenzo, Nadine S. Tare, Joseph M. Plocinski & William R. Benjamin

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  1. Kim W. McIntyre
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  2. Joel Unowsky
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  4. Nadine S. Tare
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  5. Joseph M. Plocinski
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  6. William R. Benjamin
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McIntyre, K.W., Unowsky, J., DeLorenzo, W. et al. Stimulation of hematopoiesis and antibacterial resistance by interleukin-1. Biotherapy 1, 319–325 (1989). https://doi.org/10.1007/BF02171008

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