Biotherapy

, Volume 2, Issue 4, pp 337–345

Interleukin-3

  • Gerard Wagemaker
  • Herman Burger
  • Francis C. J. M. van Gils
  • Rob W. van Leen
  • Jenne J. Wielenga
Article

DOI: 10.1007/BF02170083

Cite this article as:
Wagemaker, G., Burger, H., van Gils, F.C.J.M. et al. Biotherapy (1990) 2: 337. doi:10.1007/BF02170083
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Abstract

Interleukin-3 (IL-3) is a hemopoietic growth factor involved in the survival, proliferation and differentiation of multipotent hemopoietic cells. In five mammalian species, including man, the gene encoding IL-3 has been isolated and expressed to yield the mature recombinant proteins. The human IL-3 gene encodes a protein of 133 amino acids with two conserved cysteine residues and 2 potential N-linked glycosylation sites; human native IL-3 has not been characterized. Comparison of the IL-3 genes revealed a more rapid evolutionary divergence than has been observed for other hemopoietic growth factors, and, hence, a more pronounced species specificity of the functional proteins was found. In agreement with its stimulatory action on immature multipotent cells, thein vivo actions of homologous recombinant IL-3 in nonhuman primates include a highly increased production of blood cells along the neutrophilic, eosinophilic and basophilic granulocyte as well as the monocyte, red cell and platelet lineages.

Key words

interleukin-3 IL-3 hemopoietic growth factors molecular biology biological effects applications 

Copyright information

© Kluwer Academic Publishers 1990

Authors and Affiliations

  • Gerard Wagemaker
    • 1
    • 2
  • Herman Burger
    • 2
  • Francis C. J. M. van Gils
    • 1
  • Rob W. van Leen
    • 3
  • Jenne J. Wielenga
    • 1
  1. 1.Institute RadiobiologyErasmus UniversityRijswijkThe Netherlands
  2. 2.Institute of Applied Radiobiology and Immunology TNORijswijk
  3. 3.Royal Gist-brocades NVDelftThe Netherlands
  4. 4.Fred Hutchinson Cancer Research CenterSeattleUSA

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