Lasers in Medical Science

, Volume 11, Issue 3, pp 199–204

Infra-red tomography of port-wine-stain blood vessels in human skin

  • J. S. Nelson
  • T. E. Milner
  • B. S. Tanenbaum
  • D. M. Goodman
  • M. J. C. Van Gemert
Article

DOI: 10.1007/BF02156765

Cite this article as:
Nelson, J.S., Milner, T.E., Tanenbaum, B.S. et al. Laser Med Sci (1996) 11: 199. doi:10.1007/BF02156765

Abstract

Specifying the distribution of laser energy within a tissue is the first step towards understanding and capitalizing on a variety of laser-tissue interactions. Whether photothermal, photochemical or photomechanical in nature, laser-tissue interactions begin with the absorption of photon energy. The spatial distribution of photon absorption specifies the required laser exposure to be delivered and the extent of subsequent therapeutic action. Using infra-red tomography (IRT), the broad, long-term objective of this research is the development of a tomographic reconstruction algorithm as a means to determine: (1) the depths and physical dimensions of discrete subsurface port-wine-stain (PWS) blood vessels in human skin; and (2) the initial space-dependent temperature increase in PWS blood vessels immediately following pulsed laser exposure. In this report, preliminary studies are described which demonstrate the potential application of IRT in the clinical management of PWS patients.

Key words

Port-wine stain Infra-red tomography Laser treatment Blood vessel Photothermolysis 

Copyright information

© W.B. Saunders Company Ltd. 1996

Authors and Affiliations

  • J. S. Nelson
    • 1
  • T. E. Milner
    • 1
  • B. S. Tanenbaum
    • 2
  • D. M. Goodman
    • 3
  • M. J. C. Van Gemert
    • 4
  1. 1.Beckman Laser Institute and Medical ClinicUniversity of California, IrvineIrvineUSA
  2. 2.Department of EngineeringHarvey Mudd CollegeClaremontUSA
  3. 3.Imaging Sciences DivisionLawrence Livermore National LaboratoryLivermoreUSA
  4. 4.Laser Center, Academic Medical CenterUniversity of AmsterdamThe Netherlands