Archives of gynecology

, Volume 240, Issue 4, pp 217-223

Liver structure and function during long-term treatment with cyproterone acetate

  • E. KaiserAffiliated withFachbereich Gynäkologie/Gynäkologische Endokrinologie, Stiftung Deutsche Klinik für Diagnostik Wiesbaden GmbH
  • , H. S. GrunerAffiliated withFachbereich Gastroenterologie, Stiftung Deutsche Klinik für Diagnostik Wiesbaden GmbH

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Animal experiments and clinical observations have raised the question of liver function in patients on long-term, high-dose administration of sex steroids. The effective treatment of androgenisation demands the prolonged administration of the antiandrogen cyproterone acetate (CPA), which is also a highly effective progestogen. Biochemical tests of liver function and ultrasonographic examinations were performed in 77 women who had been treated with CPA given in the reverse sequential scheme — 100 mg CPA/day from the 1st–10th day combined with 2 mg CPA + 0.05 mg ethinylestradiol/day from the 1st-21st day of each treatment cycle — for 3 to 11 years. No disturbances of the liver structure or function were found.

Key words

Androgenisation Cyproterone acetate Liver function Steroids Liver neoplasm