Archives of gynecology

, Volume 240, Issue 4, pp 217–223

Liver structure and function during long-term treatment with cyproterone acetate

  • E. Kaiser
  • H. S. Gruner
Originals

DOI: 10.1007/BF02134071

Cite this article as:
Kaiser, E. & Gruner, H.S. Arch. Gynecol. (1987) 240: 217. doi:10.1007/BF02134071

Summary

Animal experiments and clinical observations have raised the question of liver function in patients on long-term, high-dose administration of sex steroids. The effective treatment of androgenisation demands the prolonged administration of the antiandrogen cyproterone acetate (CPA), which is also a highly effective progestogen. Biochemical tests of liver function and ultrasonographic examinations were performed in 77 women who had been treated with CPA given in the reverse sequential scheme — 100 mg CPA/day from the 1st–10th day combined with 2 mg CPA + 0.05 mg ethinylestradiol/day from the 1st-21st day of each treatment cycle — for 3 to 11 years. No disturbances of the liver structure or function were found.

Key words

Androgenisation Cyproterone acetate Liver function Steroids Liver neoplasm 

Copyright information

© Springer-Verlag 1987

Authors and Affiliations

  • E. Kaiser
    • 1
  • H. S. Gruner
    • 2
  1. 1.Fachbereich Gynäkologie/Gynäkologische EndokrinologieStiftung Deutsche Klinik für Diagnostik Wiesbaden GmbHWiesbadenFederal Republic of Germany
  2. 2.Fachbereich GastroenterologieStiftung Deutsche Klinik für Diagnostik Wiesbaden GmbHWiesbadenFederal Republic of Germany