, Volume 48, Issue 8, pp 741–745

Deciduogenic effects of mediators of the polyphosphatidylinositol pathway in pseudopregnant mice

  • J. M. Kyd
  • R. N. Murdoch
Research Articles

DOI: 10.1007/BF02124291

Cite this article as:
Kyd, J.M. & Murdoch, R.N. Experientia (1992) 48: 741. doi:10.1007/BF02124291


Intraluminal injections (15 μl) of either concanavalin A (125 μg) or ionophore A 23187 (0.01 μmol) induced a decidual cell reaction (DCR) in the uterus of day 4.5 pseudopregnant mice. However, when these agents were administered in different combinations with each other or with CaCl2 (15 μmol) and phorbol-12-myristate-13-acetate (1.6 nmol), interacting effects occurred to either enhance or inhibit each of the others' independent deciduogenic capacities. The results suggest that the polyphosphatidylinositol pathway and Ca2+ are involved in the induction of the DCR in mice with complex interactions occurring between the active components of the pathway to modulate the outcome of the transformation process.

Key words

Decidualizationpseudopregnancyuterine biochemistrypolyphosphatidylinositol pathwayconcanavalin Acalcium ionophorephorbol ester

Copyright information

© Birkhäuser Verlag Basel 1992

Authors and Affiliations

  • J. M. Kyd
    • 1
  • R. N. Murdoch
    • 1
  1. 1.Department of Biological SciencesThe University of NewcastleNewcastleAustralia