Article

Medical Microbiology and Immunology

, Volume 173, Issue 4, pp 171-177

First online:

Replication of Borna disease virus in rats: age-dependent differences in tissue distribution

  • S. HerzogAffiliated withInstitut für Virologie, Justus-Liebig-Universität Gie\en
  • , C. KompterAffiliated withInstitut für Veterinär-Pathologie, Justus-Liebig-Universität Gie\en
  • , K. FreseAffiliated withInstitut für Veterinär-Pathologie, Justus-Liebig-Universität Gie\en
  • , R. RottAffiliated withInstitut für Virologie, Justus-Liebig-Universität Gie\en

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Abstract

There are age-dependent differences in the tissue distribution of Borna disease (BD) virus in rats infected intracerebrally. While in adult rats BD virus replication is restricted to neural cells, in neonatally infected rats infectious virus or viral antigens were found in the cells of most organs. The possibility that differences in the immune status between newborn and adult animals are responsible for different tissue susceptibility could be excluded.