Experientia

, Volume 48, Issue 7, pp 659–662

Effects of some GABAergic agents on quinine-induced seizures in mice

  • G. J. Amabeoku
  • O. Chikuni
Research Articles

DOI: 10.1007/BF02118313

Cite this article as:
Amabeoku, G.J. & Chikuni, O. Experientia (1992) 48: 659. doi:10.1007/BF02118313

Abstract

The effects of some GABAergic agents on seizures induced by quinine were studied in mice. Muscimol, AOAA, DABA and baclofen significantly protected mice against quinine-induced convulsions. Bicuculline effectively enhanced quinine-induced convulsions, and significantly attenuated the protective effects of muscimol, AOAA and DABA against convulsions induced by quinine. Diazepam and phenobarbitone significantly protected mice against convulsions induced by quinine. However, phenytoin did not affect quinine-induced seizures to any significant degree. These results indicate that the convulsant effect of quinine may be due to a disturbance in the status of the GABAergic system.

Key words

QuinineseizuresGABAergic agentsGABAergic mechanismdiazepamphenobarbitonephenytoin

Copyright information

© Birkhäuser Verlag 1992

Authors and Affiliations

  • G. J. Amabeoku
    • 1
  • O. Chikuni
    • 1
  1. 1.Department of Clinical Pharmacology, Medical SchoolUniversity of ZimbabweHarareZimbabwe