Immunogenetics

, Volume 32, Issue 3, pp 183–186

The human genes for the α and γ subunits of the mast cell receptor for immunoglobulin E are located on human chromosome band 1823

Authors

  • Maryvonne Le Coniat
    • Unité INSERM U 301 and SDI No. 15954 I CNRSInstitut de Génétique Moléculaire
  • Jean-Pierre Kinet
    • Molecular Allergy and Immunology SectionNational Institute of Allergy and Infectious Diseases, National Institutes of Health
  • Roland Berger
    • Unité INSERM U 301 and SDI No. 15954 I CNRSInstitut de Génétique Moléculaire
Original Articles

DOI: 10.1007/BF02114971

Cite this article as:
Le Coniat, M., Kinet, J. & Berger, R. Immunogenetics (1990) 32: 183. doi:10.1007/BF02114971

Abstract

The receptor with high affinity for immunoglobulin E (FcERI) is a key molecule in triggering the allergic reaction. It isα tetrameric complex of oneα subunit, oneβ subunit, and two disulfide-linkedγ subunits. This receptor is present exclusively on mast cells and basophils. Molecules identical to theγ subunit of FcεRI also formα cell surface complex with other Fc receptors such as mouse FcγRIIa in macrophages and most probably with human FcγRIII (CD16) in natural killer (NK) cells. Here we show by in situ hybridization that the human genes for theα (FCER1A) and γ subunits (FCER1 G) of FcERI and the gene for FcγRIII (FCGR3, CD16) are located on human chromosome band 1823.

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© Springer-Verlag 1990