Original Papers

Archives of gynecology

, Volume 233, Issue 3, pp 211-215

First online:

Serum PAPP-A in normal pregnancy: Relationship to fetal and maternal characteristics

  • J. G. WestergaardAffiliated withDept. of Obstetrics and Gynaecology, Odense University Hospital
  • , B. TeisnerAffiliated withInstitute of Medical Microbiology, Odense University
  • , J. G. GrudzinskasAffiliated withDept. of Obstertrics and Gynaecology, University of Sydney

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Pregnancy associated plasma protein A (PAPP-A) was measured in maternal serum by electroimmunoassy in 414 women (with subsequent normal pregnancy outcome) during the 38th week of pregnancy. PAPP-A levels were examined in relation to maternal and fetal characteristics, revealing a statistically significant relationship with maternal weight, placental weight, fetal sex and gravidity. The correlation of PAPP-A levels to fetal sex and gravidity could not be explained by differences in placental or maternal weight. Mean levels of PAPP-A were also not significantly different in relation to fetal sex.

Key words

Pregnancy associated plasma protein A Pregnancy protein Measurement of serum PAPP-A Normal pregnancy