Journal of Bioenergetics and Biomembranes

, Volume 27, Issue 3, pp 311–330

Experimental and theoretical analysis of the interaction between cytochromec and cytochromeb5

  • A. Grant Mauk
  • Marcia R. Mauk
  • Geoffrey R. Moore
  • Scott H. Northrup
Article

DOI: 10.1007/BF02110101

Cite this article as:
Mauk, A.G., Mauk, M.R., Moore, G.R. et al. J Bioenerg Biomembr (1995) 27: 311. doi:10.1007/BF02110101

Abstract

Experimental and theoretical investigation of the interaction of cytochromec and cytochromeb5 performed over nearly twenty years has produced considerable insight into the manner in which these proteins recognize and bind to each other. The results of these studies and the experimental and theoretical strategies that have been developed to achieve these results have significant implications for understanding the behavior of similar complexes formed by more complex and less-well characterized electron transfer proteins. The current review provides a comprehensive summary and critical evaluation of the literature on which the current status of our understanding of the interaction of cytochromec and cytochromeb5 is based. The general issues related to the study of electron transfer complexes of this type are discussed and some new directions for future investigation of such systems are considered.

Key words

Cytochromeccytochromeb5protein-protein interactionelectron transferNMR spectroscopymolecular modelling

Copyright information

© Plenum Publishing Corporation 1995

Authors and Affiliations

  • A. Grant Mauk
    • 1
  • Marcia R. Mauk
    • 1
  • Geoffrey R. Moore
    • 2
  • Scott H. Northrup
    • 3
  1. 1.Department of Biochemistry and Molecular BiologyUniversity of British ColumbiaVancouverCanada
  2. 2.School of Chemical SciencesUniversity of East AngliaNorwichUK
  3. 3.Department of ChemistryTennessee Technological UniversityCookeville