Journal of Molecular Evolution

, Volume 33, Issue 5, pp 426–430

Rearrangements of mitochondrial transfer RNA genes in marsupials

Authors

  • Svante Pääbo
    • Division of Biochemistry and Molecular BiologyUniversity of California
    • Department of ZoologyUniversity of Munich
  • W. Kelley Thomas
    • Division of Biochemistry and Molecular BiologyUniversity of California
  • Kristina M. Whitfield
    • Division of Biochemistry and Molecular BiologyUniversity of California
  • Yoshinori Kumazawa
    • Division of Biochemistry and Molecular BiologyUniversity of California
    • Department of Life ChemistryTokyo Institute of Technology
  • Allan C. Wilson
    • Division of Biochemistry and Molecular BiologyUniversity of California
Article

DOI: 10.1007/BF02103134

Cite this article as:
Pääbo, S., Thomas, W.K., Whitfield, K.M. et al. J Mol Evol (1991) 33: 426. doi:10.1007/BF02103134

Summary

The nucleotide sequences of the mitochondrial origin of light-strand replication and the five tRNA genes surrounding it were determined for three marsupials. The region was found to be rearranged, leaving only the tRNATyr gene at the same position as in placental mammals andXenopus. Distribution of the same rearranged genotype among two marsupial families indicates that the events causing the rearrangements took place in an early marsupial ancestor. The putative mitochondrial light-strand origin of replication in marsupials contains a hairpin structure similar to other vertebrate origins and, in addition, extensive flanking sequences that are not found in other vertebrates. Sequence comparisons among the marsupials as well as placentals indicate that the tRNATyr gene has been evolving under more constraints than the other tRNA genes.

Key words

Mitochondrial DNAMarsupialstRNA genesGenome organizationEvolutionary constraints
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Copyright information

© Springer-Verlag New York Inc 1991