Journal of Molecular Evolution

, Volume 32, Issue 6, pp 493–503

The compositional properties of human genes

  • Brahim Aïssani
  • Giuseppe D'Onofrio
  • Dominique Mouchiroud
  • Katheleen Gardiner
  • Christian Gautier
  • Giorgio Bernardi
Article

DOI: 10.1007/BF02102651

Cite this article as:
Aïssani, B., D'Onofrio, G., Mouchiroud, D. et al. J Mol Evol (1991) 32: 493. doi:10.1007/BF02102651

Summary

The present work represents the first attempt to study in greater detail previously proposed compositional correlations in genomes, based on a body of additional data relating to gene localizations as well as to extended flanking sequences extracted from gene banks. We have investigated the correlations that exist between (1) the GC levels of exons of human genes, and (2) the GC levels of either intergenic sequences or introns associated with the genes under consideration. In both cases, linear relationships with slopes close to unity were found. The similarity of the linear relationships indicates similar GC levels in intergenic sequences and introns located in the same isochores. Moreover, both intergenic sequences and introns showed GC levels 5–10% lower than the corresponding exons. The above findings considerably strengthen the previously drawn conclusion that coding and noncoding sequences (both inter- and intragenic) from the same isochores of the human genome are compositionally correlated. In addition, we find linear correlations between the GC levels of codon positions and of the intergenic sequences or introns associated with the corresponding genes, as well as among the GC levels of codon positions of genes.

Key words

Human genomeGene localizationIsochoresCoding sequencesIntronsCodon positions

Copyright information

© Springer-Verlag New York Inc 1991

Authors and Affiliations

  • Brahim Aïssani
    • 1
  • Giuseppe D'Onofrio
    • 1
  • Dominique Mouchiroud
    • 2
  • Katheleen Gardiner
    • 3
  • Christian Gautier
    • 2
  • Giorgio Bernardi
    • 1
  1. 1.Laboratoire de Génétique MoléculaireInstitut Jacques MonodParisFrance
  2. 2.Laboratoire de Biométrie, Génétique et Biologie des Populations, U.R.A. 243Université Claude BernardVilleurbanneFrance
  3. 3.Eleanor Roosevelt Institute for Cancer ResearchDenverUSA
  4. 4.Stazione ZoologicaNaplesItaly