The effects of guanine and cytosine variation on dinucleotide frequency and amino acid composition in the human genome
- Cite this article as:
- Hanai, R. & Wada, A. J Mol Evol (1988) 27: 321. doi:10.1007/BF02101194
One hundred twelve human DNA sequences were analyzed with respect to dinucleotide frequency and amino acid composition. The variation in guanine and cytosine (G+C) content revealed: (1) at 2–3 and 3-1 doublet positions CG discrimination is attenuated at high G+C, but TA disfavor is enhanced, and (2) several amino acids are subject to G+C change. These findings have been reported in part for collections of sequences from various species. The present study confirms that in a single organism-the human-the G+C effects do exist. Aspects of the argument that connects G+C with protein thermal stability are also discussed.