Journal of Molecular Evolution

, Volume 27, Issue 4, pp 321–325

The effects of guanine and cytosine variation on dinucleotide frequency and amino acid composition in the human genome

  • Ryo Hanai
  • Akiyoshi Wada

DOI: 10.1007/BF02101194

Cite this article as:
Hanai, R. & Wada, A. J Mol Evol (1988) 27: 321. doi:10.1007/BF02101194


One hundred twelve human DNA sequences were analyzed with respect to dinucleotide frequency and amino acid composition. The variation in guanine and cytosine (G+C) content revealed: (1) at 2–3 and 3-1 doublet positions CG discrimination is attenuated at high G+C, but TA disfavor is enhanced, and (2) several amino acids are subject to G+C change. These findings have been reported in part for collections of sequences from various species. The present study confirms that in a single organism-the human-the G+C effects do exist. Aspects of the argument that connects G+C with protein thermal stability are also discussed.

Key words

G+C content Dinucleotide frequency Amino acid composition Human genome Protein stability 

Copyright information

© Springer-Verlag New York Inc 1988

Authors and Affiliations

  • Ryo Hanai
    • 1
  • Akiyoshi Wada
    • 1
  1. 1.Department of Physics, Faculty of ScienceThe University of TokyoTokyoJapan

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