Antibody response to a two-dose influenza vaccine regimen in adult lymphoma patients on chemotherapy
Cite this article as: Lo, W., Whimbey, E., Elting, L. et al. Eur. J. Clin. Microbiol. Infect. Dis. (1993) 12: 778. doi:10.1007/BF02098469 Abstract
A study was conducted to determine if a two-dose regimen of influenza vaccine would enhance the immunologic response of 41 patients with lymphoma receiving chemotherapy. Hemagglutinin-inhibiting antibody responses to influenza A/H1N1, A/H3N2 and B virus occurred in 32 %, 24 % and 20 % of patients following one dose, and in 49 %, 41 % and 46 % of patients following two doses, respectively. Responses to one or more vaccine components occurred in 42 % of patients after one dose and in 71 % after two doses. Fifty percent of the patients who did not respond after one dose responded after two doses. A two-dose regimen of influenza immunization may significantly enhance the response rate of cancer patients receiving chemotherapy.
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