European Journal of Clinical Microbiology

, Volume 6, Issue 1, pp 18–21

Acellular pertussis vaccine in adults: Adverse reactions and immune response

  • M. Granström
  • M. Thorén
  • M. Blennow
  • M. Tiru
  • Y. Sato
Article

DOI: 10.1007/BF02097184

Cite this article as:
Granström, M., Thorén, M., Blennow, M. et al. Eur. J, Clin. Microbiol. (1987) 6: 18. doi:10.1007/BF02097184

Abstract

An acellular pertussis vaccine JNIH-6 containing pertussis toxin and filamentous hemagglutinin was evaluated in adult volunteers with regard to adverse reactions and antibody response. Adverse reactions were few and mild. A late onset local reaction was seen in 22 of the 47 vaccinees (47 %) as compared to none of the 20 subjects receiving a placebo, the carrier solution of aluminium phosphate of the vaccine. The reaction, which manifested itself on the 6th to 8th day after vaccination, consisted in all cases of an induration and/or swelling considered insignificant by the majority of the subjects. The reaction was only found in vaccinees receiving a first dose of vaccine and was independent of the prevaccination antitoxin level. The vaccine induced a highly satisfactory antibody response to both filamentous hemagglutinin and pertussis toxin.

Copyright information

© Friedr. Vieweg & Sohn Verlagsgesellschaft mbH 1987

Authors and Affiliations

  • M. Granström
    • 1
  • M. Thorén
    • 1
  • M. Blennow
    • 2
  • M. Tiru
    • 1
  • Y. Sato
    • 3
  1. 1.Department of Vaccine ProductionNational Bacteriological LaboratoryStockholmSweden
  2. 2.Sachs' Childrens HospitalStockholmSweden
  3. 3.National Institute of HealthTokyoJapan