Article

Journal of Mammary Gland Biology and Neoplasia

, Volume 1, Issue 1, pp 21-35

First online:

Role of mesenchymal-epithelial interactions in mammary gland development

  • Gerald R. CunhaAffiliated withAnatomy Department and Reproductive Endocrinology Center, University of California
  • , Yun Kit HomAffiliated withAnatomy Department and Reproductive Endocrinology Center, University of California

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Abstract

The mammary gland is a hormone-target organ derived from epidermis and develops as a result of reciprocal mesenchymal-epithelial interactions. The induction of mammary differentiation from indifferent epidermal cells by mammary mesenchyme implies induction of the complement of hormone receptors characteristic of normal mammary epithelium in cells of the epidermis. Considering the facts that mammary epithelial differentiation is induced by mammary mesenchyme and that certain aspects of hormone response (androgen-induced mammary regression) are inextricably linked to mesenchymal-epithelial interactions, it is evident that the biology of the mammary gland arises from and is maintained via cell-cell interactions. As a corollary, perturbation of stromal-epithelial interactions in adulthood may play a role in mammary carcinogenesis and in turn may provide opportunities for differentiation therapy.

Key words

Mesenchymal-epithelial interactions stromal-epithelial interactions mammary mesenchyme androgen receptors Wnt-1 keratinocyte growth factor mammary gland development ductal morphogenesis end buds mammary fat pad