, Volume 39, Issue 6, pp 1365-1369

Duodenal diaphragmlike stricture induced by acetylsalicylic acid

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Many reports have mentioned the role of nonsteroidal antiinflammatory drugs in inducing diaphragmlike strictures in the small and large bowel. These lesions are mostly seen in patients with chronic use of nonsteroidal antiinflammatory drugs. We report the case of a 57-year-old man who developed a diaphragmlike stricture in the second part of the duodenum. The patient had been using a preparation containing acetylsalicylic acid during many years. Although a congenital origin of the diaphragm is not completely excluded, we postulate that this stricture probably occurred as a result of acetylsalicylic acid-induced ulcerations, followed by submucosal fibrosis.