Digestive Diseases and Sciences

, Volume 41, Issue 9, pp 1814–1818

Influence of spasmolytic analgesics on motility of sphincter of oddi

  • G. Brandstätter
  • S. Schinzel
  • H. Wurzer
Pancreatic And Biliary Disorders

DOI: 10.1007/BF02088751

Cite this article as:
Brandstätter, G., Schinzel, S. & Wurzer, H. Digest Dis Sci (1996) 41: 1814. doi:10.1007/BF02088751

Abstract

The effects on the sphincter of Oddi of intravenous administration of dipyrone, 2.5 g; tramadol, 50 mg; indomethacin, 75 mg;N-butylscopolamine, 20 mg; and nitroglycerin, 1 mg, in comparison to physiological saline were assessed in a single-blind study in 36 patients hospitalized with upper abdominal pain. Basal sphincter pressure and sphincter motility were measured for a 5-min period after treatment by endoscopic manometry. Nitroglycerin and dipyrone both caused a significant fall in basal sphincter pressure, whileN-butylscopolamine and nitroglycerin produced a significant decrease in contraction frequency. Therefore, dipyrone, in contrast to tramadol and indomethacin, exhibits spasmolytic activity in addition to analgesia in biliary pain.

Key words

endoscopydigestive systemanalgesicsbile ductbiliary tract

Copyright information

© Plenum Publishing Corporation 1996

Authors and Affiliations

  • G. Brandstätter
    • 1
    • 2
  • S. Schinzel
    • 1
    • 2
  • H. Wurzer
    • 1
    • 2
  1. 1.From the University ClinicGrazAustria
  2. 2.Biometric Group VPI/Medical DepartmentFrankfurt/M.Germany
  3. 3.Medizinische Abteilung, Department für GastroenterologieLandeskrankenhaus-Universitätskliniken Graz, IIGrazAustria