Digestive Diseases and Sciences

, Volume 41, Issue 6, pp 1108–1131

Short-term treatment of gastric ulcer

A meta-analytical evaluation of blind trials
  • Francesco Di Mario
  • Giuseppe Battaglia
  • Gioacchino Leandro
  • Giovanni Grasso
  • Fabio Vianello
  • Sergio Vigneri
Esophageal, Gastric, And Duodenal Disorders

DOI: 10.1007/BF02088227

Cite this article as:
Mario, F.D., Battaglia, G., Leandro, G. et al. Digest Dis Sci (1996) 41: 1108. doi:10.1007/BF02088227

Abstract

Gastric ulcer is relatively infrequent, and clinical trials are often based on small-sized samples. The aim of this study was to define the “gold standard” therapy of active gastric ulcer. We included all single- or double-blind clinical trials on the short-term treatment of gastric ulcer. All the articles published over the period 1977–1994 were reviewed. Meta-analysis was done with both fixed and random effect models; results were shown using Galbraith's radial plot. Forty-eight papers comprising 52 studies were evaluated. Cimetidine, ranitidine, and famotidine proved significantly better than placebo [odds ratio (OR) and 95% confidence interval (CI 95%) at four to six weeks were: 2.67 (2.03–3.52), 3.94 (2.28–6.80), 1.76 (1.08–2.88), respectively]. Cimetidine and ranitidine had results comparable with the newer H2 blockers [OR (CI 95%) at four weeks: 1.16 (0.91–1.47), 1.11 (0.80–1.55), respectively]. H2 blockers were proved comparable with either sucralfate [OR (CI 95%) at eight weeks: 0.81 (0.37–1.79)] or bismuth [OR (CI 95%) at four to six weeks: 0.67 (0.37–1.20)]. Omeprazole is more effective than H2 blockers [OR (CI 95%) at four weeks: 2.00 (1.57–2.55)]. It is concluded that H2 blockers are preferred to either a placebo or sucralfate for short-term gastric ulcer treatment; the newer H2 blockers do not have significant advantages over the older types; omeprazole can be regarded as the “gold standard” for active gastric ulcer treatment.

Key words

gastric ulcerpeptic ulcer therapymeta-analysisH2 blockersomeprazole

Copyright information

© Plenum Publishing Corporation 1996

Authors and Affiliations

  • Francesco Di Mario
    • 1
    • 2
    • 3
    • 4
  • Giuseppe Battaglia
    • 1
    • 2
    • 3
    • 4
  • Gioacchino Leandro
    • 1
    • 2
    • 3
    • 4
  • Giovanni Grasso
    • 1
    • 2
    • 3
    • 4
  • Fabio Vianello
    • 1
    • 2
    • 3
    • 4
  • Sergio Vigneri
    • 1
    • 2
    • 3
    • 4
  1. 1.From the Divisione di Gastroenterologia “R. Farini,” Università di PaduaItaly
  2. 2.Servizio di Gastroenterologia ed Endoscopia Digestiva, OOCCRR SSVeniceItaly
  3. 3.IRCCS Specializzato in Gastroenterologia “S. De Bellis,” Castellana Grotte (BA)Italy
  4. 4.Clinica MedicaUniversità di PalermoPalermoItaly