Digestive Diseases and Sciences

, Volume 39, Issue 12, pp 2671–2678

Systemic treatment with recombinant human epidermal growth factor accelerates healing of sclerotherapy-induced esophageal ulcers and prevents esophageal stricture formations in pigs

  • Claus Orloff Juhl
  • Lars Vinter-Jensen
  • Lone Susanne Jensen
  • Ebba Nexø
  • Jens Christian Djurhuus
  • Esam Zapher Dajani
Liver: Infections, Inflammatory, And Metabolic Disorders

DOI: 10.1007/BF02087708

Cite this article as:
Juhl, C.O., Vinter-Jensen, L., Jensen, L.S. et al. Digest Dis Sci (1994) 39: 2671. doi:10.1007/BF02087708

Abstract

Human epidermal growth factor (EGF), a small polypeptide (6 kDa) with mitogenic properties, has been implicated in the protection of gastrointestinal mucosal integrity. The efficacy of EGF in the prevention and healing of sclerotherapy-induced esophageal lesions was investigated in 24 minipigs with surgically induced portal hypertension. In addition, the effect of EGF on intragastric acidity and pharmacokinetics was investigated as possible means to explain its protective mechanism of action. The animals underwent three weekly sessions of sclerotherapy with polidocanol 2% and were concomitantly and for an additional three weeks treated with either placebo or EGF administered paravenously in the esophagus and/or subcutaneously. The subcutaneous treatment with EGF significantly (P<0.05) reduced esophageal stricture and scar formations associated with sclerotherapy. Gastric pH values were significantly (P<0.01) elevated only in animals receiving subcutaneous injections of EGF. Furthermore, the subcutaneous administration of EGF was associated with unexpected prolonged plasma concentration of the peptide. These results suggest a possible clinical value of EGF as an adjunctive treatment with the sclerotherapy.

Key words

epidermal growth factorsclerotherapyesophageal ulcers

Copyright information

© Plenum Publishing Corporation 1994

Authors and Affiliations

  • Claus Orloff Juhl
    • 3
    • 1
    • 2
  • Lars Vinter-Jensen
    • 3
    • 1
    • 2
  • Lone Susanne Jensen
    • 3
    • 1
    • 2
  • Ebba Nexø
    • 3
    • 1
    • 2
  • Jens Christian Djurhuus
    • 3
    • 1
    • 2
  • Esam Zapher Dajani
    • 3
    • 1
    • 2
  1. 1.Department of Clinical BiochemistryUniversity Hospital of Aarhus, Section KHDenmark
  2. 2.International Drug Development Consultants, a Division of Mid GulfU.S.A., Inc.Chicago
  3. 3.Institute of Experimental Clinical ResearchUniversity Hospital of Aarhus, Section SkejbyAarhus CDenmark