Digestive Diseases and Sciences

, Volume 39, Issue 5, pp 993–998

Fat-soluble vitamin concentration in chronic alcohol-induced pancreatitis

Relationship with steatorrhea
  • F. Marotta
  • D. Labadarios
  • L. Frazer
  • A. Girdwood
  • I. N. Marks
Article

DOI: 10.1007/BF02087550

Cite this article as:
Marotta, F., Labadarios, D., Frazer, L. et al. Digest Dis Sci (1994) 39: 993. doi:10.1007/BF02087550

Abstract

In order to study the fat-soluble vitamin concentration of patients with chronic alcohol-induced pancreatitis (CAIP) we measured vitamins A and E, total lipids, and retinol-binding protein (RBP) in the plasma of 44 patients with CAIP and 83 controls (44 healthy controls; 39 Crohn's disease patients). Mean plasma vitamin E and vitamin E/total lipid ratio were significantly lower in CAIP when compared with either control or Crohn's disease groups. A low vitamin E/total lipid ratio was found in 75% of CAIP patients (91% with steatorrhea) and a ratio less than 1.0 was virtually 100% predictive of steatorrhea. The mean plasma vitamin A level for the CAIP group was significantly lower (overall 16%, 38% with steatorrhea) than in controls. Patients with CAIP show subnormal plasma levels vitamin E more often as compared to vitamin A. Further, the plasma vitamin E/total lipids ratio may be a sensitive and practical means in the detection and follow-up of steatorrhea in these patients.

Key words

pancreatitissteatorrheafat-soluble vitamin

Copyright information

© Plenum Publishing Corporation 1994

Authors and Affiliations

  • F. Marotta
    • 1
    • 2
  • D. Labadarios
    • 1
    • 2
  • L. Frazer
    • 1
    • 2
  • A. Girdwood
    • 1
    • 2
  • I. N. Marks
    • 1
    • 2
  1. 1.From the Gastrointestinal ClinicGroote Schuur HospitalCape Town
  2. 2.Department of Human NutritionStellenbosch University, Tygerberg HospitalSouth Africa
  3. 3.Liver Unit CrespiNiguarda HospitalMilanItaly