European Journal of Pediatrics

, Volume 155, Issue 2, pp 77–80

Left ventricular volume and mass in children on growth hormone therapy compared with untreated children

  • Daniela Heuschmann
  • O. Butenandt
  • M. Vogel

DOI: 10.1007/BF02075754

Cite this article as:
Heuschmann, D., Butenandt, O. & Vogel, M. Eur J Pediatr (1996) 155: 77. doi:10.1007/BF02075754


The myotropic effects of growth hormone (GH) have long been known. An excess of GH as in acromegaly, causes various problems within the circulatory system including cardiac hypertrophy. Although the latter has not been reported as a complication of GH therapy in children, we assessed this possibility in 54 children. Ninety-six echocardiographic studies were performed, in which bisectional images were analysed by Simpson's rule to determine left ventricular volume and mass. Of special interest were 47 results obtained from girls with Ullrich-Turner-syndrome (UTS) treated with supraphysiological doses of GH. Our results showed a significant increase of the myocardial mass in children on GH therapy compared with untreated children, as well as a dose related effect of GH on cardiac mass in girls and cardiac volume in boys. No cardiac hypertrophy, however, could be observed; the increase in muscular mass merely amounting to a normalization of previously low values.

Key words

Cardiac hypertrophyEchocardiographyGrowth hormone therapy



familial short stature


growth hormone


intra-uterine growth retardation


Ullrich-Turner syndrome

Copyright information

© Springer-Verlag 1996

Authors and Affiliations

  • Daniela Heuschmann
    • 1
  • O. Butenandt
    • 1
  • M. Vogel
    • 2
  1. 1.Pädiatrische AuxologieDr. v. Haunersches KinderspitalMünchenGermany
  2. 2.Deutsches HerzzentrumMünchenGermany