European Journal of Pediatrics

, Volume 152, Issue 1, pp 55–58

Mild prematurity and respiratory functions

  • T. Todisco
  • F. M. de Benedictis
  • L. Iannacci
  • S. Baglioni
  • A. Eslami
  • E. Todisco
  • M. Dottorini
Neonatology

DOI: 10.1007/BF02072517

Cite this article as:
Todisco, T., de Benedictis, F.M., Iannacci, L. et al. Eur J Pediatr (1993) 152: 55. doi:10.1007/BF02072517

Abstract

Pulmonary function tests and bronchial reactivity to methacholine (MCH) were measured in 34 randomly selected prematures (21 males, 13 females; mean age 11.6 years; mean gestational age 34.9 weeks; mean birth weight 1980 g) and in 34 siblings (22 males, 12 females; mean age 12.5 years; mean gestational age 39.5 weeks; mean birth weight 3030 g). None had suffered neonatal respiratory distress syndrome or had been artificially ventilated. Prematurely born children had a residual volume (RV) and residual volume/total lung capacity (RV/TLC) significantly (P<0.01) increased compared to controls, although the mean values of both groups were still within the upper limits of normal. Furthermore, an increase of closing volume/vital capacity and closing capacity/total lung capacity (CC/TLC) was observed in most patients with increased RV and RV/TLC. No significant difference was observed for bronchial responsiveness to MCH between prematurely born and control children (11.8% and 5.9% of hyperreactive subjects, respectively). Maternal smoking during pregnancy was prevalent in prematures with impaired respiratory functions. In conclusion clinically normal children of smoking mothers who have survived prematurity but present some respiratory function impairment compared to their born-at-term siblings, should be fully informed and protected from risk factors for chronic obstructive pulmonary disease (COPD) in adult life.

Key words

Prematurity Respiratory functions Maternal smoking during pregnancy Chronic obstructive pulmonary disease 

Abbreviations

CC

closing capacity

CV

closing volume

FEV

forced expiratory volume in 1s

MCH

methacholine

MEF25, 50, 75

maximum expiratory flow at 25%, 50% and 75% of expiratory vital capacity

PC20

dose of MCH provoking a 20% fall in FEV1

RDS

respiratory distress syndrome

RV

residual volume

TLC

total lung capacity

VC

Vital capacity

Copyright information

© Springer-Verlag 1993

Authors and Affiliations

  • T. Todisco
    • 1
  • F. M. de Benedictis
    • 2
  • L. Iannacci
    • 1
  • S. Baglioni
    • 1
  • A. Eslami
    • 1
  • E. Todisco
    • 1
  • M. Dottorini
    • 1
  1. 1.Department of PulmonologyUniversity Hospital of PerugiaPerugiaItaly
  2. 2.Department of PaediatricsUniversity Hospital of PerugiaPerugiaItaly