European Journal of Pediatrics

, Volume 152, Issue 2, pp 120–124

The immune response in iron-deficient young children: Effect of iron supplementation on cell-mediated immunity

  • H. Thibault
  • P. Galan
  • F. Selz
  • P. Preziosi
  • C. Olivier
  • J. Badoual
  • S. Hercberg
Immunology/Allergology

DOI: 10.1007/BF02072487

Cite this article as:
Thibault, H., Galan, P., Selz, F. et al. Eur J Pediatr (1993) 152: 120. doi:10.1007/BF02072487

Abstract

The effects of iron deficiency on immunity remain controversial. This study was designed to assess the impact of iron supplementation on the immune status, in 81 children aged 6 months–3 years, at high risk for iron deficiency, using a longitudinal double blind randomised and placebo-controlled study. Lymphocytes of iron-deficient children produced less interleukin-2 in vitro. Iron supplementation for 2 months increased mean corpuscular volume, serum ferritin and serum transferrin, but had no effect on the parameters of T-cell mediated immunity. The lower interleukin-2 levels in iron-deficient suggest that cell-mediated immunity may be impaired in iron deficiency.

Key words

Iron deficiency Iron supplementation Immune functions Cell-mediated immunity Interleukin-2 

Abbreviations

CRP

Creactive protein

PBMC

peripheral blood mononuclear cells

PHA

phytohaemagglutinin A

Copyright information

© Springer-Verlag 1993

Authors and Affiliations

  • H. Thibault
    • 1
  • P. Galan
    • 1
  • F. Selz
    • 2
  • P. Preziosi
    • 1
  • C. Olivier
    • 3
  • J. Badoual
    • 4
  • S. Hercberg
    • 1
  1. 1.Institut Scientifique et Technique de la Nutrition et de l'AlimentationCNAMParisFrance
  2. 2.INSERM U 132Hopital Necker-Enfants MaladesParisFrance
  3. 3.Service de PédiatrieHopital Louis MourierColombesFrance
  4. 4.Service de Pédiatrie générale et néonatologieHôpital Saint-Vincent-de PaulParisFrance

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