Follow up of growth and steroids in premature adrenarche
- Cite this article as:
- Pere, A., Perheentupa, J., Peter, M. et al. Eur J Pediatr (1995) 154: 346. doi:10.1007/BF02072100
In a follow up study of 34 patients with premature adrenarche we examined serum adrenal androgen levels and growth. The majority (28/34) showed an upward bend in the growth curve which, at the mean age of 2.3 years, preceded other signs of adrenarche on average by 3.8 years. Pubertal growth spurt was missing or reduced in 50% of the patients (8/16), however, final height did not differ from that expected from parental heights. Adrenal androgens did not remain elevated at adolescence. The mean age at menarche for all the girls was 0.5 years younger than in the general population.
Our findings imply that premature adrenarche may start earlier than previously recognized. Compared to ordinary growth these children seen to use a greater part of their potential for adult height already at that early age.
Key wordsPremature adrenarcheGrowthPubertyMenarcheAdrenal androgens
parent-specific expected height standard deviation score
final height standard deviation score
pubic hair stage
standard deviation score
sex hormone-binding globulin
relative weight expressed as the percentage deviation from the median weight for height and sex