Reviews

Pharmaceutisch Weekblad

, Volume 13, Issue 6, pp 238-243

First online:

Oxytocics for the prevention of post-partum haemorrhages

A review
  • P. W. J. Van DongenAffiliated withDepartment of Obstetrics and Gynaecology, University Hospital Nijmegen
  • , J. Van RoosmalenAffiliated withDepartment of Obstetrics and Gynaecology, University Hospital Leiden
  • , C. N. De BoerAffiliated withDepartment of Obstetrics and Gynaecology, Catharina Hospital Eindhoven
  • , J. Van RooijAffiliated withDepartment of Obstetrics and Gynaecology, University Hospital Leiden

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Abstract

Secale alkaloids, oxytocin and prostaglandins are used to prevent post-partum haemorrhage (post-partum haemorrhage defined as blood loss ⩾ 500 ml). Any oxytocic drug administered in the third stage of labour reduces the blood loss with approximately 40% and hence the incidence of post-partum haemorrhage from 10 to 6%. Therefore, routine active management of the third stage with an oxytocic drug is strongly advocated. Because of the fewest side-effects oxytocin is regarded as the best drug available at this moment.

Keywords

Drug stability Ergometrine Hemorrhage, postpartum/prevention and control Oxytocin Prostaglandins Risk factors Side effects