European Journal of Clinical Microbiology

, Volume 6, Issue 5, pp 591–593

Lectin-Mediated bacterial adhesion to human tissue

  • J. Beuth
  • H. L. Ko
  • G. Uhlenbruck
  • G. Pulverer
Notes

DOI: 10.1007/BF02014258

Cite this article as:
Beuth, J., Ko, H.L., Uhlenbruck, G. et al. Eur. J, Clin. Microbiol. (1987) 6: 591. doi:10.1007/BF02014258

Abstract

In vitro experiments with frozen sections of human lung and kidney demonstrated that adhesion ofStreptococcus pneumoniaePn 629 Type 14 andPseudomonas aeruginosaATCC 27853 to human cells was mediated by bacterial lectins (adhesins) with N-acetyl-D-glucosamine/D-galactose or N-acetyl-neuraminic acid specificity. Blocking of the lectin binding sites on bacterial surfaces with competitive carbohydrates completely prevented the bacterial adherence,whereas non-specific carbohydrates (D-mannose, D-xylose) did not inhibit adherence.

Copyright information

© Friedr. Vieweg & Sohn Verlagsgesellschaft mbH 1987

Authors and Affiliations

  • J. Beuth
    • 1
  • H. L. Ko
    • 1
  • G. Uhlenbruck
    • 2
  • G. Pulverer
    • 1
  1. 1.Institute of HygieneUniversity of CologneCologne 41FRG
  2. 2.Department of ImmunobiologyMedical University Clinic 1Cologne 41FRG