Inhibition of anaphylactic shock by gadolinium chloride-induced Kupffer cell blockade
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Data in the literature concerning the role of macrophages in anaphylaxis are contradictory. In the present study, the effect of macrophage blockade induced by gadolinium chloride (GdCl3) on anaphylactic shock is investigated. Our observations show that GdCl3 prevents lethal anaphylactic shock in mice sensitized to ovalbumin. Gadolinium chloride given i.v. in a dose of 1 mg/100 g body weight 24 or 48 h before the elicitation of anaphylactic shock resulted in 80% survival, compared with the 43% survival in the control group. The same dose of this rare-earth metal salt also greatly reduced the mortality in mice sensitized with ovalbumin containingBordetella pertussis vaccine, and similarly abrogated the symptoms of anaphylaxis, including the accumulation of serotonin and histamine in the liver. The results suggest that macrophages play an important role in mouse anaphylaxis.
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- Inhibition of anaphylactic shock by gadolinium chloride-induced Kupffer cell blockade
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Volume 41, Issue 1 Supplement, pp C97-C98
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- 1. Department of Surgery, Albert Szent-Györgyi Medical University, P.O. Box 531, 6701, Szeged, Hungary
- 2. Institute of Pathophysiology, Albert Szent-Györgyi Medical University, P.O. Box 531, 6701, Szeged, Hungary
- 3. Institute of Experimental Surgery, Albert Szent-Györgyi Medical University, P.O. Box 531, 6701, Szeged, Hungary
- 4. Department of Dermatology, Albert Szent-Györgyi Medical University, P.O. Box 531, 6701, Szeged, Hungary