Agents and Actions

, Volume 34, Issue 1, pp 285–288

Synovial activation of chondrocytes: Evidence for complex cytokine interactions

  • G. Bandara
  • H. I. Georgescu
  • C. W. Lin
  • C. H. Evans
C. Gordon van Arman Scholarship Competition (Finalists)

DOI: 10.1007/BF01993304

Cite this article as:
Bandara, G., Georgescu, H.I., Lin, C.W. et al. Agents and Actions (1991) 34: 285. doi:10.1007/BF01993304

Abstract

Synoviocytes secrete factors which induce the synthesis of neutral metalloproteinases (NMP) and prostaglandin E2 (PGE2) by chondrocytes in a response called “chondrocyte activation”. We analyzed synovial chondrocyte activating factors (CAF) for the presence of cytokines which modulated the NMP production by articular chondrocytes. These studies suggested the presence of several other cytokines in addition to interleukin-1 (IL-1). Both resting and activated synoviocytes contained mRNA for basic fibroblast growth factor (bFGF) which is a synergist for IL-1 induced NMP production, and secreted bFGF into their culture media. They also expressed mRNA for transforming growth factorβ (TGFβ) which inhibits IL-1 induced NMP production. These cells also produce tumor necrosis factorα (TNFα) and trace amounts of interleukin-6 (IL-6). In addition to these there is evidence for a synovial activator of chondrocytes which is distinct from IL-1. Since a number of recombinant cytokines including TNFα, IL-6 and bFGF failed to activate chondrocytes, this could be a novel cytokine.

Copyright information

© Birkhäuser Verlag 1991

Authors and Affiliations

  • G. Bandara
    • 1
  • H. I. Georgescu
    • 1
  • C. W. Lin
    • 1
  • C. H. Evans
    • 1
  1. 1.Ferguson Laboratory for Orthopaedic ResearchUniversity of Pittsburgh School of MedicinePittsburghUSA

Personalised recommendations