Article

Experientia

, Volume 32, Issue 5, pp 659-660

First online:

Histamine as an extremely potent releaser of vasopressin in the rat

  • J. DogteromAffiliated withNetherlands Central Institute for Brain ResearchRudolf Magnus Institute for Pharmacology, Medical Faculty, University of Utrecht
  • , Tj. B. van Wimersma GreidanusAffiliated withNetherlands Central Institute for Brain ResearchRudolf Magnus Institute for Pharmacology, Medical Faculty, University of Utrecht
  • , D. De WiedAffiliated withNetherlands Central Institute for Brain ResearchRudolf Magnus Institute for Pharmacology, Medical Faculty, University of Utrecht

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Summary

Intraperitoneal and intraventricular injection of histamine induces a very fast and high elevation of vasopressin in rat plasma as determined by radioimmunoassay. The effects are dose and time related. The intraventricular injection is more effective with regard to time and dose than the intraperitoneal injection.