, Volume 32, Issue 5, pp 645–647

The effects of tryptophol on immune responses and its implications toward trypanosome-induced immunosuppression

  • S. B. Ackerman
  • J. R. Seed

DOI: 10.1007/BF01990212

Cite this article as:
Ackerman, S.B. & Seed, J.R. Experientia (1976) 32: 645. doi:10.1007/BF01990212


Daily administrations of tryptophol to laboratory rodents resulted in significantly depressed antibody production to heterologous red blood cell challenge, but did not alter cellular-mediated responses to oxazalone. These results suggest that trypanosome-produced tryptophol may account for the immunodepression observed during trypanosomiasis.

Copyright information

© Birkhäuser Verlag 1976

Authors and Affiliations

  • S. B. Ackerman
    • 1
  • J. R. Seed
    • 1
  1. 1.Laboratory of Parasitology, Department of BiologyTulane UniversityNew OrleansUSA
  2. 2.Department of ZoologyUniversity of GeorgiaAthensUSA